Our lead development candidate BO-112 is a best-in-class intra-tumoral treatment with demonstrated clinical efficacy and safety in more than 120 patients with various tumor types. BO-112 in combination with pembrolizumab demonstrated potent efficacy in patients with advanced melanoma who previously failed treatment with immune checkpoint inhibitors. BO-112 is currently being investigated in monotherapy for treatment of primary basal cell carcinoma and in combination with immune-checkpoint inhibitors and radiotherapy for sarcomas and non-small cell lung cancer.
BO-112 Monotherapy
A Multicenter, Open-label, Non-randomized, Clinical Trial to Evaluate Safety, Tolerability and Preliminary Efficacy of Intra-lesional BO-112 in Patients With Resectable Primary Low and High-Risk Basal Cell Carcinoma.
Independent
BO-112 + Pembrolizumab
Single Arm Clinical Study to Evaluate the Efficacy and Safety of Intratumoral Administration of BO-112 in Combination With Pembrolizumab in Subjects That Have Progressed on Anti-PD-1-based Therapy for Stage III or IV Melanoma.
Independent
BO-112 + Pembrolizumab
Colorectal or Gastric/GEJ Cancer With Liver Metastasis
Open-label Clinical Study of Intratumoural Administration of BO-112 in Combination With Pembrolizumab in Subjects With Liver Metastasis From Colorectal Cancer or Gastric/Gastro-oesophageal Junction Cancer
Independent
BO-112 monotherapy
BO-112 + Pembrolizumab or Nivolumab
An Exploratory First in Human Phase I Clinical and Pharmacokinetic Study of Intra-tumoral Administration of BO-112 in Adult Patients With Aggressive Solid Tumors, With an Extension Cohort in Combination With Anti-PD1 Treatment.
Independent
BO-112 + Ablative Radiotherapy (SABR) + Nivolumab
Open-label Clinical Study of Intratumoral Administration of BO-112 in Combination With Radiotherapy and Nivolumab in Patients With Metastatic PD- 1/PD-L1 Refractory Non-small Cell Lung Cancer
Clínica Universidad de Navarra, Universidad de Navarra
BO-112 + Nivolumab + Radiation Therapy
Study of Nivolumab and Intratumoral BO 112 for Resectable Soft Tissue Sarcoma
Jonsson Comprehensive Cancer Center
BO-112 + Pembrolizumab
Pilot Feasibility Study of Intratumoral BO-112 in Combination With Pembrolizumab for Advanced Hepatocellular Carcinoma
Jonsson Comprehensive Cancer Center